Palmitoyl Tripeptide-38
Also known as: Palmitoyl Tripeptide-38, Matrixyl Synthe'6, Pal-KTTKS-like
What It Is
A lipid-conjugated tripeptide developed to stimulate the synthesis of six key skin matrix molecules simultaneously. Commercially known as Matrixyl Synthe'6® from Sederma/Croda.
What It Does
Stimulates the production of six extracellular matrix proteins: collagen I, III, and IV, fibronectin, hyaluronic acid, and laminin-5. Designed as a more comprehensive matrix-regenerating peptide than earlier Matrixyl generations.
Best For
Benefits
- Targets 6 different matrix proteins simultaneously — the broadest matrix-regenerating peptide claim among common cosmetic peptides
- Branded as Matrixyl Synthe'6 — third generation in the Matrixyl line with expanded matrix targets
- Clinical data from Sederma shows improved wrinkle depth and skin density
When to Be Careful
- As a newer peptide, has fewer independent studies than the original Matrixyl peptides
- Typically used in small concentrations — clinical results at cosmetic use levels may be more modest than branded studies suggest
Third generation Matrixyl — signals coverage of collagen I, III, IV, fibronectin, HA, and laminin is a compelling multi-target claim. The Matrixyl name has strong consumer recognition from the original peptide.
"Stimulating 6 matrix proteins" sounds dramatic but this doesn't mean it works 6x better. Each target has varying evidence, and cosmetic concentrations always limit real-world results.
Peptide serum — morning or evening. Consistent daily use.
Palmitoyl Tripeptide-1 + Tetrapeptide-7 (covers additional matrix pathways), Hyaluronic Acid
Very well tolerated. No known irritation concerns.
No known overuse reactions.