Ingredient Guide
Palmitoyl Isoleucine
Also known as: Pal-Isoleucine, Palmitoyl Isoleucine 1%
All skin types
What It Is
A lipopeptide (palmitic acid bonded to the amino acid isoleucine) used in skincare for extracellular matrix support. Part of the Volufiline™ plumping system.
What It Does
Palmitoyl isoleucine may inhibit hyaluronidase (an enzyme that breaks down hyaluronic acid) and support the structural components responsible for skin plumpness and firmness — complementing the adipocyte-stimulating mechanism of Volufiline™.
Best For
Facial plumpingVolume supportExtracellular matrix support
Benefits
- Potential hyaluronidase inhibition: may help preserve the skin's natural HA
- Extracellular matrix support: maintains structural plumping components
- Synergistic with Volufiline™ in targeted plumping formulas
When to Be Careful
- Limited independent research — most data from branded patent literature
- Gradual mechanism requiring consistent long-term use
ItGirlies Ingredient Intelligence
Best Routine Slot
Evening or twice daily as part of a plumping serum.
Good Match For
People interested in volume-loss correction and extracellular matrix support.
Proceed Carefully If…
No known concerns.
Signs You May Be Overdoing It
No typical signs of overuse.
Commonly Found In
Plumping SerumsAnti-Aging Serums
Products Containing Palmitoyl Isoleucine
FAQs About Palmitoyl Isoleucine
What does palmitoyl isoleucine do in skincare?
A lipopeptide linked to extracellular matrix support and potential hyaluronidase inhibition — may help preserve natural hyaluronic acid. Appears in Volufiline™-based plumping formulas.