Matrixyl Synthe'6
Also known as: Palmitoyl Tripeptide-38, Matrixyl Synthe6, Matrixyl Synthe'6 Peptide
What It Is
A second-generation matrikine peptide from Sederma — Palmitoyl Tripeptide-38 — that works alongside Matrixyl 3000 by targeting a broader range of structural skin proteins than its predecessor.
What It Does
Matrixyl Synthe'6 stimulates synthesis of six structural skin components: Collagen I, III, and IV, Fibronectin, Laminin-5 (now laminin-332), and Hyaluronic Acid. By expanding beyond what Matrixyl 3000 targets alone, it provides more comprehensive extracellular matrix support and deeper anti-aging coverage.
Best For
Benefits
- Stimulates 6 structural proteins vs. Matrixyl 3000's narrower collagen/elastin focus
- Addresses deeper wrinkles alongside fine lines
- Supports Laminin-5 and Fibronectin — key components of the dermo-epidermal junction
- Zero irritation risk — appropriate for all skin types including sensitive
- Synergistic with Matrixyl 3000 in combined formulas (Matrixyl 10%)
When to Be Careful
- Same gradual timeline as Matrixyl 3000 — 8–12 weeks for visible results
- Expensive as an isolated ingredient — most accessibly found in multi-peptide formulas
Matrixyl Synthe'6 represents a genuine evolution from Matrixyl 3000. Sederma data shows statistically significant reductions in wrinkle volume. When combined with Matrixyl 3000 in a 10% total concentration formula, you're getting the broadest possible peptide-driven collagen support currently available at an accessible price.
People assume Matrixyl Synthe'6 replaces Matrixyl 3000. They are designed to be used together — their protein targets overlap partially but their combined effect is more comprehensive than either alone.
AM or PM — no restrictions. Pairs naturally with SPF in the morning.
People focusing on anti-aging who want comprehensive structural support without retinol or acids.
No known concerns.
No signs of overuse.